Saturday, February 13, 2010

Reverse Transcriptase Inhibitors in Development

I found some interesting information on some newer drugs this week one of them being Etravirine which is used in antiretroviral therapy.

Etravirine is a antiretroviral non-nucleoside reverse transcriptase inhibitor which in non medical terms means it stops HIV from multiplying by inhibiting and/or preventing the reverse transcriptase enzymess from working and turns the genetic material RNA into DNA.




The drug is more used in people that have already used serveral combinations of drugs to fight the HIV infection.



I guess one of the main problems when making drugs for HIV is that it tends to mutate creating new copies slightly different than the original virus. Some viruses will develope resistance to one drug as well as other ARV's ....this is known as cross resistance. Etravirine is one of the drugs that shows much more promise when controling the virus that as resistance to other drugs.










Did you know: Etravirine doses are recommended to be around 400 milligrams or 2 tablets per day the wholesale cose is said to be around $5.45 per tablet which is somewhat in the lower range.



2 comments:

  1. I'm sorry, Devin, but this blog is late. All blogs are due by Wed of each week if you want the points associated with them. It isn't fair to the other students who post by Wed so they can read each others blog on Thursday and Friday.

    Where is your blog about you and how you are progressing in this class. All I see is your research. You need to start doing both in your blogs.


    You might want to do a cost comparison at some point to show the students the cost of each drug for a year.

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  2. I just realized you actually did this blog earlier as it was due on the 17th. You have my sincerest apology for saying it was late. Because of my error, I'll give you bonus points.

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